Journal of Speech, Language, and Hearing Research Vol.55 1220-1231 August 2012. doi:10.1044/1092-4388(2011/11-0152)
© American Speech-Language-Hearing Association
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Tutorial

Fundamental Approaches in Molecular Biology for Communication Sciences and Disorders

Rebecca S. Bartletta
Marie E. Jettéa
Suzanne N. Kinga
Allison Schasera
Susan L. Thibeaulta
a University of Wisconsin—Madison

Correspondence to Rebecca S. Bartlett: bartlett{at}surgery.wisc.edu

Purpose: This contemporary tutorial will introduce general principles of molecular biology, common deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and protein assays and their relevance in the field of communication sciences and disorders.

Method: Over the past 2 decades, knowledge of the molecular pathophysiology of human disease has increased at a remarkable pace. Most of this progress can be attributed to concomitant advances in basic molecular biology and, specifically, the development of an ever-expanding armamentarium of technologies for analysis of DNA, RNA, and protein structure and function. Details of these methodologies, their limitations, and examples from the communication sciences and disorders literature are presented.

Results/Conclusions: The use of molecular biology techniques in the fields of speech, language, and hearing sciences is increasing, facilitating the need for an understanding of molecular biology fundamentals and common experimental assays.

KEY WORDS: molecular biology, DNA, RNA, transcription, translation, genomics, proteomics


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