JSLHR
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Journal of Speech, Language, and Hearing Research Vol.51 586-595 June 2008. doi:10.1044/1092-4388(2008/042)
© American Speech-Language-Hearing Association
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow My Folders
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by Thomas, L. B.
Right arrow Articles by Stemple, J. C.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Thomas, L. B.
Right arrow Articles by Stemple, J. C.

Laryngeal Muscles Are Spared in the Dystrophin Deficient mdx Mouse

Lisa B. Thomas
Gayle L. Joseph
Tracey D. Adkins
Francisco H. Andrade
Joseph C. Stemple
University of Kentucky, Lexington

Contact author: Lisa B. Thomas, who is now with the Department of Communication Disorders, Marshall University, 1 John Marshall Drive, Huntington, WV 25755. E-mail: thomasl{at}marshall.edu.

Purpose: Duchenne muscular dystrophy (DMD) is caused by the loss of the cytoskeletal protein, dystrophin. The disease leads to severe and progressive skeletal muscle wasting. Interestingly, the disease spares some muscles. The purpose of the study was to determine the effects of dystrophin deficiency on 2 intrinsic laryngeal muscles, the posterior cricoarytenoid and the thyroarytenoid, in the mouse model.

Method: Larynges from dystrophin-deficient mdx and normal mice were examined histologically.

Results: Results demonstrate that despite the absence of dystrophin in the mdx laryngeal muscles, membrane damage, inflammation, necrosis, and regeneration were not detected in the assays performed.

Conclusions: The authors concluded that these muscles are 1 of only a few muscle groups spared in this model of dystrophin deficiency. The muscles may count on intrinsic and adaptive protective mechanisms to cope with the absence of dystrophin. Identifying these protective mechanisms may improve DMD management. The study also highlights the unique aspects of the selected laryngeal skeletal muscles and their dissimilarity to limb skeletal muscle.

KEY WORDS: laryngeal, muscles, muscular dystrophy, thyroarytenoid, posterior cricoarytenoid






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
All ASHA Journals AJA AJSLP JSLHR LSHSS
Copyright © 2008 by the American Speech-Language-Hearing Association.