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Journal of Speech, Language, and Hearing Research Vol.51 S259-S275 February 2008. doi:10.1044/1092-4388(2008/020)
© American Speech-Language-Hearing Association
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Neuroplasticity Supplement

Translational Research in Aphasia: From Neuroscience to Neurorehabilitation

Anastasia M. Raymer
Old Dominion University, Norfolk, VA

Pelagie Beeson
Audrey Holland
University of Arizona, Tucson

Diane Kendall
VA Brain Rehabilitation Research Center, Gainesville, FL, and University of Florida, Gainesville

Lynn M. Maher
DeBakey VA Medical Center, Houston, TX, and Baylor College of Medicine, Houston, TX

Nadine Martin
Temple University, Philadelphia, PA

Laura Murray
University of Indiana—Bloomington

Miranda Rose
La Trobe University, Melbourne, Australia

Cynthia K. Thompson
Northwestern University, Chicago, IL

Lyn Turkstra
University of Wisconsin—Madison

Lori Altmann
University of Florida

Mary Boyle
Montclair State University, Montclair, NJ

Tim Conway
University of Florida

William Hula
University of Pittsburgh

Kevin Kearns
Massachusetts General Hospital Institute of Health Professions, Boston, MA

Brenda Rapp
Johns Hopkins University

Nina Simmons-Mackie
Southeastern Louisiana University

Leslie J. Gonzalez Rothi
VA Brain Rehabilitation Research Center, Gainesville, FL, and University of Florida

Contact author: Anastasia M. Raymer, 110 Child Study Center, Old Dominion University, Norfolk, VA 23529-0136. E-mail: sraymer{at}odu.edu.

Purpose: In this article, the authors encapsulate discussions of the Language Work Group that took place as part of the Workshop in Plasticity/NeuroRehabilitation Research at the University of Florida in April 2005.

Method: In this narrative review, they define neuroplasticity and review studies that demonstrate neural changes associated with aphasia recovery and treatment. The authors then summarize basic science evidence from animals, human cognition, and computational neuroscience that is relevant to aphasia treatment research. They then turn to the aphasia treatment literature in which evidence exists to support several of the neuroscience principles.

Conclusion: Despite the extant aphasia treatment literature, many questions remain regarding how neuroscience principles can be manipulated to maximize aphasia recovery and treatment. They propose a framework, incorporating some of these principles, that may serve as a potential roadmap for future investigations of aphasia treatment and recovery. In addition to translational investigations from basic to clinical science, the authors propose several areas in which translation can occur from clinical to basic science to contribute to the fundamental knowledge base of neurorehabilitation. This article is intended to reinvigorate interest in delineating the factors influencing successful recovery from aphasia through basic, translational, and clinical research.

KEY WORDS: aphasia, rehabilitation, plasticity






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